Medicinal Chemistry of Novel Anti-Diabetic Drugs
نویسنده
چکیده
Diabetes mellitus is a common metabolic disorder affecting millions of people worldwide. The prevalence of this chronic, endocrine condition continues to grow, from a world-wide prevalence of 221 million in 2010 to a projected 300 million in 2030 [1, 2]. The majority (~90%) of patients suffering from diabetes mellitus have type 2 while about 10% have type 1. Type 1 diabetes is caused by immunological destruction of pancreatic beta cells leading to absolute insulin deficiency. On the other hand, type 2 diabetes is associated with deficient insulin secretion and/or insulin resistance. The etiology of diabetes mellitus is multifactorial involving both genetic and environmental factors.
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